RANTES (acronym for Regulated upon Activation, Normal T cell Expressed and presumably Secreted), was initially discovered by subtractive hybridization as a transcript expressed in T cells but not B cells. Eosinophil-chemotactic activities released by thrombinstimulated human platelets have also been purified and found to be identical to RANTES. Besides T cells and platelets, RANTES has been reported to be produced by renal tubular epithelium, synovial fibroblasts and selected tumor cells. _x000B_Human RANTES cDNA encodes a highly basic 91 amino acid residue precursor polypeptide with a 23 amino acid residue hydrophobic signal peptide that is cleaved to generate the 68 amino acid residue mature protein. Murine RANTES has also been cloned. Human and mouse RANTES share approximately 85% sequence homology at the amino acid level and exhibit cross-species activities.
Antibody come from
Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with T-cell lymphoma biopsy and mouse myeloma cells.
Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antigen-antibody binding interaction
RANTES - Control Lysate
Antibody is raised in
Antibody's reacts with
Antibody's reacts with these species
This antibody doesn't cross react with other species
No Data Available
Antibody's suited for
Antibody can be used for staining of human and mouse frozen and paraffin-embedded tissue sections. Optimal concentration should be evaluated by serial dilutions.
1. Van Vliet, A., et al. Distribution of fibronectin isoforms in human renal disease. J. Pathol. 2001, 193, 256-262._x000B__x000B_2. Athanassiadou, P., et al., Moc-31, fibronectin and CEA in the differential diagnosis of malignant effusions: an immunocytochemical study. Pathol. Oncol. Res. 2000, 6, 100-103._x000B__x000B_3. Menzin, A.W., et al. Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants. Cancer 1998, 82, 152-158.
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Isotype or positive controls by peptides, antibodies and deactivated samples.