NCC-4 (also known as HCC-4) is a CC chemokine. It is a 97 amino acid protein. It exhibits less than 30% sequence identity to other CC chemokines. NCC-4 chemoattracts human monocytes and THP-1 cells. However it does not chemoattract resting lymphocytes or neutrophils. It has been found to supress proliferation of myeloid progenitor cells and induces calcium flux in THP-1 cells. This calcium flux can be desensitized by exposure to RANTES which suggests that NCC-4 and RANTES share the same receptor in THP-1 cells.
Antibody come from
Hybridoma produced by the fusion of splenocytes from mice immunized with protein preparation from a homogenate of a human mammary tumor and mouse myeloma cells.
Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antigen-antibody binding interaction
NCC4 - Control Lysate
Antibody is raised in
Antibody's reacts with
Antibody's reacts with these species
This antibody doesn't cross react with other species
No Data Available
Antibody's suited for
Detects human tenascin protein by Western blot at 1-5 µg/ml. Can also be used for immunohistochemistry on frozen and paraffin-embedded tissue sections and for immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.
1. Verstraeten, A.A. et al. Tenascin expression in basal cell carcinoma. Br. J. Dermatol. 1992, 127, 571-574_x000B__x000B_2. Le Poole, I.C., et al. Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion. Br. J. Dermatol. 1997, 137, 171-178_x000B__x000B_3. Rulo, H.F., et al. Normal human skin demonstrates marked site-variation of tenascin expression, not correlated to epidermal proliferation (Ki-67 binding). J. Dermatol. Sci. 1993, 5, 54-57
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Isotype or positive controls by peptides, antibodies and deactivated samples.