Matrix Metalloproteinases, matrixins
MMP2 is a ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
Research area interests
Diseases associated with MMP2 include Multicentric Osteolysis, Nodulosis, And Arthropathy and Multicentric Osteolysis Of Torg. Among its related pathways are Pathways in cancer and Integrin Pathway
Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
Matrix Metalloproteinase 2, Progelatinase A, a 72kDa Type IV Collagenase
Available target modification
Yes, after APMA activation
50 mM Tris-HCl, pH 7.0, 200 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35
> 95 %
Human recombinant progelatinase A is expressed in Sf9-insect cells using the baculovirus expression vector system and purified from cell culture supernatant. The full-length recombinant proenzyme consists of 631 amino acids.
Mentioned in the data sheet
See the data sheet
For Research Use only.
Store at -70°C
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Isotype or positive controls by peptides, antibodies and deactivated samples.
Recombinants or rec. proteins