Category

Other Reagents

Long description

RANTES (acronym for Regulated upon Activation, Normal T cell Expressed and presumably Secreted), was initially discovered by subtractive hybridization as a transcript expressed in T cells but not B cells. Eosinophil-chemotactic activities released by thrombinstimulated human platelets have also been purified and found to be identical to RANTES. Besides T cells and platelets, RANTES has been reported to be produced by renal tubular epithelium, synovial fibroblasts and selected tumor cells. _x000B_Human RANTES cDNA encodes a highly basic 91 amino acid residue precursor polypeptide with a 23 amino acid residue hydrophobic signal peptide that is cleaved to generate the 68 amino acid residue mature protein. Murine RANTES has also been cloned. Human and mouse RANTES share approximately 85% sequence homology at the amino acid level and exhibit cross-species activities.

Antibody come from

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with T-cell lymphoma biopsy and mouse myeloma cells.

Other description

Provided as solution in phosphate buffered saline with 0.08% sodium azide.

Clone

not specified

Antigen-antibody binding interaction

RANTES - Control Lysate

Antibody is raised in

see techfile

Antibody's reacts with

see techfile

Antibody's reacts with these species

This antibody doesn't cross react with other species

Antibody's specificity

No Data Available

Application

Activity Assay

Antibody's suited for

Antibody can be used for staining of human and mouse frozen and paraffin-embedded tissue sections. Optimal concentration should be evaluated by serial dilutions.

Storage

-20ºC

Relevant references

1. Van Vliet, A., et al. Distribution of fibronectin isoforms in human renal disease. J. Pathol. 2001, 193, 256-262._x000B__x000B_2. Athanassiadou, P., et al., Moc-31, fibronectin and CEA in the differential diagnosis of malignant effusions: an immunocytochemical study. Pathol. Oncol. Res. 2000, 6, 100-103._x000B__x000B_3. Menzin, A.W., et al. Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants. Cancer 1998, 82, 152-158.

Protein number

see ncbi

Warnings

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

Tissue

control

Description

Isotype or positive controls by peptides, antibodies and deactivated samples.