Category

Other Reagents

Long description

MIP-3b is related to other b chemokines, possessing 20-30% sequence identity with other b proteins. MIP-3b has been mapped to the 9p13 chromosome. This differs from other b proteins which are mapped to chromosome 17. MIP-3b is expressed in a variety of lymphoid tissues. and is down-regulated by the anti-inflammatory cytokine IL-10. Synthetic MIP-3b is chemotactic for cultured human lymphocytes and is a unique functional ligand for CCR-7. The CCR-7 receptor has been previously referred to as the Epstein-Barr virus-induced gene 1 (EBI1). CCR-7 is a chemokine receptor which is expressed in various lymphoid tissues and activated B and T lymphocytes. EBI1 is strongly up-regulated in B cells infected with Epstein-Barr virus and T cells infected with herpesvirus 6 or 7.

Antibody come from

Hybridoma produced by the fusion of splenocytes from mice immunized with cytoskeleton preparation from human A431 carcinoma cells and mouse myeloma cells.

Other description

Provided as solution in phosphate buffered saline with 0.08% sodium azide.

Clone

not specified

Antigen-antibody binding interaction

Mip3b - Control Lysate

Antibody is raised in

see techfile

Antibody's reacts with

see techfile

Antibody's reacts with these species

This antibody doesn't cross react with other species

Antibody's specificity

No Data Available

Application

Activity Assay

Antibody's suited for

Detect keratins 4,5,6,8,10,13 & 18 by Western blot. Optimal concentration should be evaluated by serial dilutions. Other Applications: Frozen Tissue Staining, Paraffin Section, Immunohistochemistry.

Storage

-20ºC

Relevant references

1. Folia Biol. 1989, 35, 373-382_x000B__x000B_2. Neoplasma 1990, 37, 333-342_x000B__x000B_3. J. Tumor Marker Oncol. 1990, 5, 219_x000B__x000B_4. Int. J. Cancer 1988, Suppl. 3, 50-55

Protein number

see ncbi

Warnings

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

Tissue

control

Description

Isotype or positive controls by peptides, antibodies and deactivated samples.