MMP 2 Zymography control (Recombinant Protein)

General information
 

Name:
MMP 2 Zymography control (Recombinant Protein)
Size:
250 µl/ 50 lanes
Catalog no:
30 131 002
Price:
230 EUR
 

Additional extra details
 

  • Protein type

    Recombinant

    Protein subtype

    EC 3.4.24.24

    Protein family

    Matrix Metalloproteinases, matrixins

  • Protein description

    MMP2 is a ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.

    Research area interests

    Diseases associated with MMP2 include Multicentric Osteolysis, Nodulosis, And Arthropathy and Multicentric Osteolysis Of Torg. Among its related pathways are Pathways in cancer and Integrin Pathway

    Package form

    liquid

  • Tested applications

    Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard

    Other names

    Matrix Metalloproteinase 2, Progelatinase A, a 72kDa Type IV Collagenase

    Peptide sequence

    MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC

  • Available target modification

    No

    Expression system

    Insect Cell

    Product Subtype

    full length

  • Active form?

    Yes, after APMA activation

    Tag

    untagged

    Contents

    50 mM Tris-HCl, pH 7.0, 200 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35

  • Protein purity

    > 95 %

    Molecular weight

    72 kDa

    UniProt number

    P08253

  • Gene number

    4313

    Abbreviation

    N/A

    Full name

    N/A

  • Other desciption

    Human recombinant progelatinase A is expressed in Sf9-insect cells using the baculovirus expression vector system and purified from cell culture supernatant. The full-length recombinant proenzyme consists of 631 amino acids.

    Purification

    Mentioned in the data sheet

    PubMed citations

    See the data sheet

  • Warnings

    For Research Use only.

    Shipping conditions

    dry ice

    Storage condition

    Store at -70°C

  • Technical datasheet

    Contact us to receive the datasheet

    Tissue

    control

    Description

    Isotype or positive controls by peptides, antibodies and deactivated samples.

  • Source

    Recombinants or rec. proteins

    Group

    recombinants