Lysophosphatidic Acid Receptor 1 (EDG2) - Control Lysate

General information
 

Name:
Lysophosphatidic Acid Receptor 1 (EDG2) - Control Lysate
Size:
100uL
Catalog no:
X1218C
Price:
168 EUR
 

Additional extra details
 

  • Category

    Other Reagents

    Long description

    Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

    Antibody come from

    n/a

  • Other description

    Provided in 10% glycerol, 0.063 M Tris-HCl (pH 6.8), 2% SDS and 0.002% bromophenol blue, 5% 2-mercaptoethanol.

    Clone

    not specified

    Antigen-antibody binding interaction

    Lysophosphatidic Acid Receptor 1 (EDG2) - Control Lysate

  • Antibody is raised in

    see techfile

    Antibody's reacts with

    see techfile

    Antibody's reacts with these species

    This antibody doesn't cross react with other species

  • Antibody's specificity

    No Data Available

    Application

    Western Blot

    Antibody's suited for

    For use as a positive control with Exalpha's EDG2 (LPA1) polyclonal antibody (Cat. No. C174P) for Western blot analysis.

  • Storage

    -20ÂșC

    Relevant references

    no information yet

    Protein number

    see ncbi

  • Warnings

    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

    Tissue

    control

    Description

    Isotype or positive controls by peptides, antibodies and deactivated samples.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.